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Suppressive effects of alginic acids loweredmolecule for the elevation
of blood glucose and the insulin secretion in human sujects

Tsuneyuki OKU1, SadakoNAKAMURA2 and Mitsuko OKAZAKI2

1Department of Nutrition, Faculty of medicine,University of Tokyo
2Nutrition Education Labolatory, Kagawa Women'sNutrition College

Suppressive effects of Alginic acids (mean M.W.about 50,000) lowered molecule on the elevation of blood glucoseand insulin secretion were investigated using 8 healthy femalesubjects. When alginic acids 5g were administered with glucose 50g, the maximal blood glucose level was significantly lower thanthat of glucose 50 g alone, and returned to the fasting levelsafter 90 min. The addition of alginic acids 10g to glucose 50gdemonstrated the stronger effects, but the addition of alginicacids 2.5g did not induce the significant effects. Serum insulinlevels showed the maximal value after 30 min and were dependent onthe blood glucose levels. On the other hand, when a soft drink(300ml) containing alginic acids 5.7g were administered withJapanese cake 100g containing carbohydrates about 60g to samesubjects, the maximal glucose levels after 30 min was significantlylower than that of glucose 50 g alone, but were not significantlydifferent from that of the placebo soft drink. In contrast, seruminsulin levels were significantly lower in the test group withalginic acids than in both the placebo group and the glucoseingestion group. These results suggest that alginic acids loweredmolecule has an inhibitory effect on the blood glucose elevationinduced by ingestion of carbohydrate-rich foods.

key words: alginic acid, dietary fiber, blood glucose, insulinlevel, suppressive effects.

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