Beet Dietary Fiber Decreased Body Fat and Increased Hypothalamic Gene Expression of the Leptin Receptor in Rats. Taro KISHIDA*, Takafumi MIZUSHIGE, Koichi SEJIMA, Kiyoshi EBIHARA Department of Biological Resources, Faculty of Agriculture, Ehime University | In epidemiological studies, dietary fiber intake is linked to body weight. We examined the effect of beet dietary fiber (BF) on body fat and energy intake: male Sprague-Dawley rats were fed either ad libitum or 2 meals per day of a non-fiber standard diet, based on AIN-76, with or without 10% BF. We also examined serum leptin concentration and hypothalamic leptin receptor B (Ob-Rb) gene expression. Dietary BF significantly decreased body fat regardless of whether rats were fed ad libitum or 2 separated meals. Dietary BF significantly decreased energy intake in the 2-times meal fed rats only. Dietary BF decreased serum leptin concentration and increased hypothalamus leptin receptor B (Ob-Rb) gene expression, regardless of whether rats were fed ad libitum or separated meals. BF might decrease body fat by enhancing leptin signal reception, although it is unknown whether decreasing energy intake contributes to decreasing body fat. |
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