Effects of Psyllium Seed Gum Supplementation on Parameters Related to Metabolic Syndrome in Genetically Obese and Diet-Induced Obese Mice. Michiko KATO，Sachie IKEGAMI，Seiichiro AOE * 1Food Function and Labeling Program the National Institute of Health and Nutrition
2 Institute of Human Culture Studies, Otsuma Women's University
3 Department of Food Science, Faculty of Home Economics, Otsuma Women`s University | We investigated the effects of psyllium seed gum supplementation on parameters related to metabolic syndrome in genetically obese and diet-induced obese mice. Sixteen male KK and DIO mice were randomly divided into 2 groups and fed either a high-fat control diet or high-fat diet containing psyllium seed gum corresponding to 5% of total dietary fiber for 55 days. Serum concentrations of cholesterol, insulin, and leptin were significantly lower in the psyllium group compared with the control group in both the KK and DIO mice. Body composition analysis showed that the mass of abdominal fat in the psyllium group was significantly lower when compared with the control group in DIO mice. There was no difference in the mass of abdominal fat between the psyllium and control group in KK mice. However, in both the KK and DIO mice, adipocytes in the abdominal fat tissues were significantly smaller in the psyllium group compared with the control group. Expression levels of mRNAs related to cholesterol metabolism were up-regulated in both groups. The effect of psyllium seed gum supplementation on obesity and hyperinsulinemia were not explained by the mRNA expression levels or the activities of the enzymes related to carbohydrate and lipid metabolism. These results suggest that psyllium seed gum added to a high-fat diet attenuates the progression of obesity and suppresses hyperinsulinemia in genetically obese and diet-induced obese mice. However, the abdominal fat accumulation response in the psyllium groups differed between the KK and DIO mice. |
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