総 説

L-アラビノースの生理機能とセカンドミール効果

柴沼 清*,井出洋子

三和澱粉工業株式会社 研究開発部

L-Arabinose is a major plant cell-wall component present in several traditional foods. L-Arabinose uncompetitively inhibits intestinal sucrase. Intake of sucrose with L-arabinose reduced the elevation of blood glucose and insulin in healthy adults. Blood glucose concentration returned to fasting levels 120 min after ingestion of sucrose with or without L-arabinose. The elevation in blood glucose levels were also suppressed in the same volunteers after immediate ingestion of a commercial adzuki bean (without L-arabinose), suggesting residual inhibition by L-arabinose. This suppression is known as the second meal effect and indicates that L-arabinose with sucrose flows very slowly in the small intestine, as suggested by in vitro and animal tests. L-Arabinose with sucrose is suggested to attach to the ES complex of sucrase and sucrose, forming the EIS complex, which is suggested intermittently flows through the small intestine. Incretin hormone secretion occurred in animal tests and can be used to indicate the region of absorption of ingested sucrose with or without L-arabinose. Ingestion of sucrose by rats (2.5 g/kg) led to secretion of GIP, indicating digested sucrose may be absorbed in the upper part of the small intestine. Ingestion of sucrose with L-arabinose (125 mg/kg) led to secretion of GLP-1 but not GIP, indicating that most of the digested sucrose may be absorbed in the lower part of the intestine. Further analysis is required to determine whether absorption of digested sucrose is reduced by L-arabinose in humans.

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