Role of Gut Microbiota in the Exercise-Induced Innate Immune Response Hiromi YANO1, 2＊, Chihiro WATANABE2, Takafumi AOKI3, Takao NAGANO4, Eri OYANAGI1 1 Department of Health and Sports Science
2 Graduate School of Health Science and Technology
3 Department of Clinical Nutrition, Kawasaki University of Medical Welfare
4 Department of Food Science and Technology, Ishikawa Prefectural University The “Open window theory” proposes that high-intensity exercise causes immediate temporary immunosuppression, which increases the risk of upper respiratory tract and other infections. In this review, we discuss the following items:（a） Immunosuppression after intense exercise is physiologically significant. （b） Intense exercise-induced immune activation in the gastrointestinal tract may also be physiologically significant. We refer to these apparently conflicting phenomena as the “Super homeostasis theory.” Furthermore, in our view, the ability of the gut microbiota to produce short-chain fatty acids from dietary fiber as a survival strategy may be associated with the “Super homeostasis theory.”
Key Words: Open window theory, Toll-like receptors, Super homeostasis theory, gut microbiota, dietary fiber. |
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