Effects of Long-term Administration ofIndigestible
Dextrin on Visceral Fat Accumulation Yuka KISHIMOTO1, ShigeruWAKABAYASHI1, Katsuto TOKUNAGA2 1Matsutani Chemical Industry co. Ltd., ResearchInstitute
2Department of lnternal Medicine, Itami CityHospital We conducted a clinical trial in order to evaluatethe effects of continual ingestion of indigestible dextrin on bothglucose and lipid metabolism, and fat accumulation and itsdistribution in human subjects. There were twelve male subjectswith either serum total - cholesterol level more than 220 mg/dl ortriacylglycerol level more than 150 mg/dl. Subjects wereconcurrently ingested 10g of indigestible dextrin with meal (3times/day) for three month. Each was subjected to a glucosetolerance test and CT scan at umbilical level, and also taken bloodsample to measure the clinical laboratory data before and after thetest period. Compared to the starting levels, percent body fat inall the subjects and the area of visceral fat in subjects withobesity were significantly decreased. Although the average peaklevel of serum glucose was more than 200 mg/dl at 60 min after 75 gglucose administration, glucose tolerance was improved and theaverage levels of serum glucose at 30, 60, and 120 min weresiguificantly reduced after the test period. Likewise, serumtotal-cholesterol and triacylglycerol levels were significantlyreduced. No adverse event such as diarrhea was observed through thetest period. In conclusion, continual ingestion of indigestibledextrin is useful for reducing the body fat accumulation,especially visceral fat.
Key words: indigestible dextrin, visceral fat, obesity, glucosetolerance, Iipid |
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