The Effects of Indigestible Dextrin on SugarTolerance (part VI):
Effects of continuous administration in WBN/Kob rat,
A Model of Spontaneous Diabetes. Shigeru WAKBAYASHI and Yuka KISHIMOTO
Nutrition Laboratory, Research Institute,
Matsutani Chemical Industry Corporation Ltd.
The moderating effect of indigestible dextrin onpostprandial rise in blood glucose level after sucrose loading hasbeen well demonstrated. In this study we conducted a continuousingestion study in WBN/Kob rats, which is known a spontaneoustype-2 diabetes model, in order to evaluate the preventive effectsof indigestible dextrin on aggravation of both glucose and lipidmetabolism caused by the high-sucrose diet. By ingesting thehigh-sucrose diet, glucose tolerance after sucrose loading wasimpaired, both fasting blood glucose and plasma total-cholesterollevels were increased, and fat accumulation was increased afterfour weeks in WBN/Kob rats and after eight weeks in Wistar rats,respectively. Despite the WBN/Kob rats kept on the high-sucrosediet, both the impairment of glucose tolerance and fat accumulationwere prominently alleviated by continuous ingestion of indigestibledextrin. Contrary, no preventing effect of pectin and corn-fiber ondeterioration of glucose metabolism was observed in thehigh-sucrose fed WBN/Kob rats.
Key word: indigestible dextrin, WBN/Kob rats, glucose tolerance,fat accumulation, sucrose |
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