Immunogloblin production regulating activity
of water-soluble dietary fibers Koji YAMADA Laboratory of Food Chemistry, Division of AppliedBiological Chemistry,
Department of Biosience and Biotechnology, Faculty of Agriculture,Kyushu University Dietary fibers exert various biological effectssuch as anti-cancer effect, improvement of serum lipid levels andintestinal flora, prevention of constipation, immunoregulatoryactivity etc. It has also been reported that water-soluble dietaryfibers exert stronger immunoglobulin (Ig) production regulatingactivity than water-insoluble cellulose. Among them, oraladministration of pectin, glucomannan, galactomannnan or chitosansmarkedly enhanced serum IgA and IgG levels and decreased serum IgElevel in Sprague-Dawley rats. They also enhanced IgA and IgGproductivities of spleen and mesenteric lymph node (MLN)lymphocytes, as well as productivity of cytokines such asinterferon-γ and tumor necrosis factor-α of MLN lymphocytes. Theseresults suggest that water-soluble dietary fibers regulate Igproduction through the regulation of cytokine production. It hasbeen shown that these dietary fibers and their sugar componentscould not stimulate Ig production of isolated lymphocytes directly.In addition, partially digested guar gum exerted weaker dietaryeffect on Ig production and lipid metabolism than intact guar gum.These results suggest that water-soluble dietary fibers exert theirbiological effects through the interaction of intestinal flora.
Key words: immunogloblin, water-soluble dietary fibers, intestinalfrola, cytokine |
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