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A Comparative Study of Barley Bran and Wheat Branon
Incidence of DMH-induced Colon Carcinoma in Rats.

Yohko SUGAWA-KATAYAMA1, MisakiHIGUCHI1, Tomoko MATSUMOTO1,
Munehiro TETSUGUCHI1, Kouji TAMAGAWA2 andTsuneyuki SUZUKI3

1Department of Food and Nutrition,Faculty of Human Life Science,
Osaka City University,
2Hakubaku Co.Ltd.
3Dept.School of Medicine, Kinki University

The effect of barley bran on incidence of coloncarcinoma was investigated in comparison with wheat bran. A totalof 80 rats of the Fischer 344 strain were divided into four groups:(1) saline-barley bran (2) 1,2-dimethylhydrazine-barley bran (3)saline-wheat bran and (4) 1,2-dimethylhydrazine-wheat bran.
The rats fed the normal diet were pre-treated by subcutaneousinjection of 1,2-dimethylhydrazine or physiological saline twice aweek for four weeks. Then the rats were fed the high fat dietcontaining barley bran or wheat bran for 37 weeks.
The incidence of colon carcinoma was almost the same between thebarley bran (53.5% ) and wheat bran (50.0%) groups. Also, the ratswith carcinoma had same numbers of the tumor per rat in the twogroups. There was no relationship between the incidence of coloncarcinoma and cecal pH or short chain fatty acid concentration.

Key words: barley bran, wheat bran, cecal short chain fatty acid,DMH-induced colon carcinoma

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