Effects of Pectin on the Lithogenic Parameters ofBile
in Gastrectomized Rats Fed a Cholesterol-Free Diet Tomihiro Miyada1, AkiraNakajima1 and Kiyoshi Ebihara2 1Department of Food and Nutrition
2Department of Biological Resources,
Faculty of Agriculture, Ehime University This study was designed to investigate the effectof pectin on the composition of bile in total gastrectomized rats.Rats were divided into the following three groups: sham-operatedrats fed the pectin-free diet, gastrectomized rats fed thePectin-free diet, and gastrectomized rats fed the Pectin-free dietsupplemented with 5% pectin (Pectin diet). The rats were fed therespective test diet for 70 days. Between the two groups fed thePectin-free diet, the bile flow, the biliary secretion of bileacid, cholesterol and phospholipid, the proportion of cholic acid(CA) , the cholic acid/chenodeoxycholic acid (CDCA) (CA/CDCA)ratio, and the primary bile acids/secondary bile acids (P/S) ratiowere higher in the bile in gastrectmized rats, but the proportionsof CDCA, ursodeoxycholic acid and lithocholic acid in the bile werelower in gastrectmized rats than in sham-operated rats. The bileflow and the biliary secretions of bile acid, cholesterol andphospholipid did not vary between the two groups of gastrectomizedrats. The proportion of CDCA in bile was significantly higher andthe CA/CDCA ratio in bile was significantly lower in thegastrectomized rats fed Pectin diet , but the proportion of thedeoxycholic acid in the bile was significantly lower in thegastrectomized rats fed the Pectin diet than in the gastrectomizedrats fed the Pectin free-diet . The P/S ratio was not affected bythe Pectin diet feeding. The results of this study suggest thatpectin may reduce the lithogenicity of bile after gastrectomy bymodifying the composition of bile acids in bile.
Key words: pectin gastrectomy bile acid bile lithogenicity rat |
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