Effects of Sodium Alginate or Partially HydrolyzedLoW-Molecular Sodium Alginate on Serum and Liver Lipid Levels andHepatic Lipogenesis in Rats Kazunari TANAKA1, ShokoNISHIZONO1, Naoko TOKUDA2, KaoriTOMINAGA2,
Shoko MAEHAMA2, Nozomi MAKINO1, and TsuneyukiOKUI1 1Graduate School of Human Health Science, SieboldUniversity of Nagasaki
2Department of Nutrition and Health Sciences, SieboldUniversity of Nagasaki Male Sprague-Dawlay rats were fed a O.5c/ccholesterol diet containing 5% cellulose, sodium alginate (SA) orpartially hydrolyzed low-molecular sodium alginate (Low-SA), asdietary fiber source, for 4 weeks. Serum and liver cholesterolconcentrations in rats fed the diet containing SA were comparableto those in rats fed the diet containing cellulose. But feeding ofLow-SA increased serum and liver cholesterol levels when comparedwith feeding of SA. Fecal total steroid excretion was decreased inthe Low-SA group. The concentration of triglyceride in serum andliver was significantly lower in the SA and Low-SA groups than inthe cellulose group. Feeding of SA reduced hepatic fatty acidsynthase activity and increased both hepatic carnitinepalmitoyltransferase activity and excretion of fecal triglyceride.Low-SA increased only the activity of carnitinepalmitoyltransferase. These results suggest that SA and Low-SAexert a triglyceride-lowering effect by the reduction of hepaticlipogenesis and/or the stimulation of fatty acid catabolism,although Low-SA, compared with SA, increased the levels of serumand liver cholesterol through the decrease of fecal steroidexcretion.
Key words: sodium alginate, Iow-molecular sodium alginate,cholesterol, triglyceride, Iipogenesis |
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