Suppressive Effect of Dietary Fiber on Elevationof erum Uric Acid Concentration Induced by Dietary Adenosine andAdenosine-5',-Monophosphate in Rats Takashi KOGUCHI1, HiromiKOGUCHI1,2, Hisao NAKAJIMA3,
Saburo TANAKA4, Yuji YAMAMOTO1, SatoshiINNAMI1,
Akio MAEKAWA1 and Tadahiro TADOKORO1 1Department of App]ied Biology and Chemistry. Faculty ofApplied Bioscience, Tokyo University of Agriculture
2Nagatanien Corporation
3Department of Food and Nutrition, Junior College ofNihon University
4Faculty of Education, Bunkyo University | This study was performed to examine the effects ofseveral klnds of dietary fiber (DF) with different physicalprop-erties on the elevation of serum uric acid concentrationinduced by dietary adenosine and adenos'ine-5'-monophosphate(5'-AMP). Male Wistar straln rats, 4 weeks old, were fed diets withpurine compounds-free and adenosine or 5'-AMP (30 mmol/ kg dieteach) together with or without 50g/kg diet of DF (cellulose,chitin. chitosan or xanthan gum) for 2O days. The concentrations ofuric acid, allantoin and urea nitrogen in serum elevated byadditions of pu-rine compounds to the fiber-free diet weresignificantly suppressed by the test DF as compared withfiber-free. This phenomenon was remarkable in the xanthan gumgroup. The suppressive effect of chitin and chltosan on theelevation of serum uric acid concentration induced by 5'-AMP wasstronger than that induced by adenosine. The present results revealthat the elevation of serum uric acid concentration induced bydietary adenosine and 5'-AMP can be suppressed by DF, and thesuppressive effect of DF varicd w[th the type of DF. Key words:adenosine, adenosine-5'-monophosphate, dietary fiber, rats, serumuric acid concentration Abbreviations used: 5'-AMP, Adenosine5'-monophosphate; DF, dietary fiber; 5'-IMP,inosine-5'-monophosphate; WHC, water-holding capacity. |
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