Effect of a Soft Drink containingGalacto-oligosaccharides on Defecation Frequency, Fecal Properties,and Fecal Microflora in Healthy Young Women Rie TAKAYAMA1, AtsushiWATANABE2, Harulni YAMAMOTO1, KazuhisaODAKA1,
Keiichiro OKABE1,2, Nozomi SAKURAI3 andYosuke AOKI3 1DDS R&D Center
2Microbial Flora Institute, Advance Co., Ltd.
3Department of Food and Health Science, Faculty of HumanLife Science, Jissen Women's University | Effects of a daily intake of soft drink containing4g of galacto-oligosaccharides (GOS) on defecation frequency, fecalproperties and fecal microflora were evaluated by a double-blindcrossover study in 51 healthy female students (average age19.7±1.2 y). The subjects were divided into two groups andgiven a 60 mL/day (containing 4 g GOS) of soft drink or a placebodrink for three weeks each with two weeks interval. Seventeensubjects of them, whose viable Bifidobacterium counts in feces wereless than 30% of the total fecal bacterial counts, were analyzedfor their fecal microflora before and after the both drinks intakeperiod. As a result, after the GOS drink intake, in 28 subjectswhose defecation was less than five days per week, significantincreases in defecation frequency and fecal volume were observedcompared to the placebo drink intake (p<0.05) or the non-intakeperiod (p<0.01). Fecal microfloral analysis revealed the numberof total anaerobic bacteria and Bifidobacteria to have increasedsignificantly compared to the placebo drink intake (p<0.05) orthe non-intake period (p<0.05, p<0.01, respectively), and theoccupation percentage of Bifidobacteria in the total count of fecalmicroflora was tended to increase compared to the placebo drinkintake or significantly increased compared to the non-intake period(p<0.05). On the other hand, the number of Clostrldlumlecithinase (+) significantly decreased compared to the non-intakeperiod (p<0.05). Furthermore, in 6 subjects, whose viableBifidobacterium counts in feces were less than 10% of the totalfecal bacterial counts before the GOS drink intake period, thenumber of Bifidobacteria and Lactobacilli increased significantly,and the occupation percentage of Bifidobacteria in the total countof fecal microflora was significantly increased compared to thenon-intake period (p<0.05, respectively). These results clearlyshow that the daily intake of the soft drink containing 4g GOS per60ml contributes to improve defecation and fecal properties throughits prebiotic effects on increasing useful intestinal bacteria andsimultaneous decreasing harmful intestinal bacteria to keep a goodintestinal environment. Key words: galacto-oligosaccharides,defecation, fecal microflora, Bifidobacterium, good intestinalenvironment, prebiotics. |
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