Dietary Intake of Dietary Fiber and Cancer Yukari EGASHIRA1, OsamuCHONAN2 1Faculty of Horticulture, Chiba University
2Yakult Central Institute for MicrobiologicalResearch | Many studies have been reported that dietary wheatbran, cellulose, resistant starch and inulin suppressedexperimental colon tumors or cancer in rats. Dietary fiber reducescontact between the intestinal contents and mucosa, and leads to !production of short-chain fatty acids, acetate, propionate, andbutyrate, which reduce pH and the conversion of primary tosecondary bile acids. Butyrate is the major source of energy forthe distal colon and it reduces cell proliferation and inducesapoptosis, factors that are associated with inhibition of thetransformation of the colonic epithelium to carcinoma. On the otherhand, dietary fiber is thought to protect against colorectal cancerin human but this view has been challenged by recent cohort studiesthat showed no protective effect. |
Return
|
