Examination for laxative effect and Safety ofsugar alcohol-containing chewing gum in healthy subjects Tsuneyuki OKU*, Mariko NAKAMURA, MichiruISHIGURO,
Kenichi TANABE, Yoshihiko YAMAGUCHI and Sadako NAKAMURA
Graduate School of Human Health Science, Siebold University ofNagasaki
Three-fold amounts of ordinary intake (2 pieces by4-times) of sugar alcohol-containing chewing gum were ingested by15 male and 15 female subjects 4-times in a day (total 24 pieces)for 1week, and the effects on blood biochemical parameters, urinaryproperty, fecal conditions including fecal frequency andconstituents and abdominal symptoms were observed. The study designwas randomized single blinded placebo controlled crossoverexperiment. A total of 24 pieces of test chewing gum containedtotal sugar alcohols 21.9g (maltitol 14.4g, xylitol 7.2g and others0.3g) and placebo gum was replaced with sucrose instead of sugaralcohols.
No high osmotic diarrhea was caused in every subject. Fecalconditions including fecal frequency and constituents were notsignificantly different between test and placebo chewing gumgroups. Abdominal symptoms were also not significantly differentbetween test and placebo chewing gum groups, but flatus frequentlyoccurred in test chewing gum group. Biochemical data and componentsof blood and urinary properties were not affected by ingestion oftest chewing gum. These results are demonstrated that even 3-foldamounts of ingestion (24 pieces) of ordinary intake of sugaralcohol-containing chewing gum in a day does not induce harmfuleffects in healthy subjects and the ordinary intake of sugaralcohol-containing chewing gum is safe.
Key words: sugar alcohol, maltitol, xylitol, Iaxative effect, fecalcondition |
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